Credentials: Oncology Department
Position title: Molecular mechanisms of steroid hormone action
Phone: (608) 265-9319
6151 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Cancer Biology; Transcriptional Mechanisms
The research interest in our laboratory is on the regulation and mechanism of action of steroid hormone receptors. Steroid hormone receptors are critical players in normal reproduction, development, metabolism and growth. They are also important in the development and treatment of a wide variety of cancers. They function as direct transcriptional regulators and have been a model for understanding basic transcriptional mechanisms for over 5 decades. Recently, it has become clear that the actions of these receptors and their transcriptional activity are dynamically regulated through post-translational modifications, control of protein stability, structural rearrangement, and protein complex assembly and disassembly. Our laboratory uses cellular, molecular, biochemical and structural biology approaches to better understand these processes and their integration. Our hope is that through an improved understanding of the basic biology of these receptors, we will contribute to improved diagnosis and treatment of hormone-dependent cancers.