Reid Alisch

Credentials: Neurological Surgery Department

Position title: Neuroepigenetics of human behavior


Phone: (608) 262-8430

Uw Psychiatric Inst & Clinics
6001 Research Park Blvd
Madison, WI 53719

Headshot of Reid Alisch

lab website:

focus groups:

Transcriptional Mechanisms; Systems Biology; Developmental Biology & Regenerative Medicine

research description:

My research focuses on the role of DNA methylation in human disease processes. My laboratory utilizes an innovative interdisciplinary combination of brain imaging and state-of-the-art molecular genetic methods to investigate molecular contributions to psychiatric disorders (e.g. schizophrenia, bipolar disorder, depression, anxiety, etc.). We extensively utilize rodent and non-human primate models to study the temporal and spatial changes of DNA methylation throughout neurodevelopment and due to prenatal/early life stimulus. Recently, we identified a gene by environment interaction that results in repetitive behaviors and social deficits, which suggested that DNA methylation (5-hydroxymethylcytosine (5hmC)) contributes to this outcome. Together, these findings will identify stress-related molecular targets in the brain that are influenced by environmentally sensitive epigenetic mechanisms and are involved in developmental brain disorders.


Neuroscience Training Program (NTP), Genetics, Endocrinology and Reproductive Physiology (ERP) 

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