Mitotic kinase function and cancer
6059 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Cell Adhesion & Cytoskeleton; Cancer Biology
My research focus is understanding mechanisms of mitotic control, primarily in human systems. To do this, my group has developed and implemented chemical biology techniques to probe kinase function at discrete times and locations within the mitotic cell. Over the next 5 years, this project will focus on dissecting signaling of kinases within the kinetochore, a 200 nm structure that links the mitotic spindle to chromosomes during mitosis. Additionally, we seek to understand how mitotic signaling goes awry in cancer and the impacts this has on the cell biology function of human cancer cells.