Credentials: Biomolecular Chemistry Department
Position title: Conservation and diversity in mechanisms that control the inheritance and expression of eukaryotic chromosomes
Phone: (608) 262-9370
5204c Biochemistry Building
420 Henry Mall
Madison, WI 53706
Molecular & Genome Biology of Microbes
The lab examines processes that occur in the nucleus, the “command center” of the eukaryotic cell. A focus is on mechanisms that regulate chromosome replication and genome stability, as well as how these processes are coordinated with chromatin structural changes to allow cells to grow and divide normally. These are fundamental questions in chromosome biology with high relevance to human development and disease. We use Saccharomyces cerevisiae (budding yeast) as a model because while the basic mechanisms we study are conserved in all eukaryotic cells, yeast let us apply a vast array of experimental approaches including molecular biology, classical and reverse genetics, genomics, cell biology and biochemistry to address our questions.