Nutritional Sciences Department
Membrane trafficking in digestive epithelia
216 Nutritional Sciences
1415 Linden Dr
Madison, WI 53706
Membrane Biology & Protein Trafficking; Physiology
My research is focused on understanding the molecular mechanisms that regulate protein secretion from digestive epithelia. Most of our work is conducted using pancreatic acini, as these cells provide a highly differentiated and polarized cell model with intact constitutive and Ca2+-regulated secretory pathways. Studies directed to understanding membrane trafficking in acinar cells are of particular importance as the major pancreatic diseases, pancreatitis and pancreatic cancer, appear to arise from pathophysiological alterations in this process.