Electrophysiology and imaging techniques are used to explore the basic mechanisms of neuronal signaling
3433 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Membrane Biology & Protein Trafficking; Physiology
Our research focuses broadly on the function of nerve terminals, both how their neurotransmitter-filled vesicles fuse with the plasma membrane and how their excitability regulates the entry of Ca2+ to trigger membrane fusion. Our investigations of presynaptic mechanisms often take us into detailed studies at the molecular level, but we also venture in the opposite direction into questions about neural circuitry. To address these questions we employ the electrophysiological methods of patch clamping and amperometry, as well as a variety of forms of microscopy to image voltage and Ca2+.