Molecular genetics of animal development
433 Babcock Dr
Madison, WI 53706
Developmental Biology & Regenerative Medicine; RNA Biology
My research focuses on molecular controls of animal development. Two major problems have spanned my career: how are germline stem cells regulated to self-renew or differentiate and how are germ cells controlled to differentiate as sperm or oocytes. We have found that Notch signaling controls an RNA regulatory network to maintain germline stem cells; a key effector is FBF, a broad spectrum repressor of differentiation. We have also found that two RNA regulatory proteins control the sperm/oocyte decision. In addition, we have made forays into controls of asymmetric cell divisions, Wnt signaling, MAPK signaling, cell cycle control, metalloproteases and organogenesis, each time making major contributions. My lab is currently focusing on Notch signaling with new reagents, downstream effectors of Notch signaling (two new key genes), effects of nutrition on germline stem cell maintenance and molecular mechanisms of sperm/oocyte regulation.