Randall Kimple
Credentials: Human Oncology Department
Position title: HPV associated cancers; therapeutic resistance in cancer
Email: rkimple@humonc.wisc.edu
Phone: (608) 263-3611
Address:
3107 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
LAB WEBSITE:
https://www.humonc.wisc.edu/team_member/randall-kimple/#research
FOCUS GROUPS:
Cancer Biology; Virology
RESEARCH DESCRIPTION:
We utilize cellular systems that include cell lines and unique early passage cell strains of both HPV-positive and HPV-negative head and neck cancer. We use these cellular systems to investigate how the HPV-oncoproteins work to modulate the response to radiation and/or chemotherapy. In particular, we focus our efforts on modulation of cellular signaling pathways such as EGFR, MEK/ERK/PI3K/Akt by the HPV proteins E5 and E6 and on DNA damage repair by the HPV protein E7.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Cellular and Molecular Pathology (CMP), Cancer Biology, Comparative Biomedical Sciences (CBMS)