Credentials: Human Oncology Department
Position title: HPV associated cancers; therapeutic resistance in cancer
Phone: (608) 263-3611
3107 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Cancer Biology; Virology
We utilize cellular systems that include cell lines and unique early passage cell strains of both HPV-positive and HPV-negative head and neck cancer. We use these cellular systems to investigate how the HPV-oncoproteins work to modulate the response to radiation and/or chemotherapy. In particular, we focus our efforts on modulation of cellular signaling pathways such as EGFR, MEK/ERK/PI3K/Akt by the HPV proteins E5 and E6 and on DNA damage repair by the HPV protein E7.