Medical Microbiology & Immunology Department
Molecular basis for sexual dimorphism
3205 Microbial Sciences Building
1550 Linden Drive
Madison, WI 53706
Cancer Biology; Immunology; Transcriptional Mechanisms
My research is focused on understanding the molecular basis for sex differences in human physiology and pathology. Many autoimmune diseases feature increased prevalence in females (~78% female overall and up to ~ 95% female for specific diseases). In contrast, infectious diseases and cancer affect more men than women. The molecular mechanisms underlying these observed sex differences are unclear. To fill this knowledge gap, we seek to define immune- and cancer-associated pathways that are differentially regulated between the two sexes using a combination of molecular, cell-based and animal-based approaches. We hope our research will shed light on the biological significance of sexual dimorphism, and provide novel ways to combat autoimmunity, infections and cancer.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Microbiology (MDTP), Cellular and Molecular Pathology (CMP), Molecular and Cellular Pharmacology (MCP), Molecular and Environmental Toxicology (METC), Endocrinology and Reproductive Physiology (ERP), Comparative Biomedical Sciences (CBMS)