Cell & Regenerative Biology Department
Mammalian Heart Regeneration
4557 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Cellular & Molecular Metabolism; Developmental Biology & Regenerative Medicine; Cellular & Molecular Metabolism; Transcriptional Mechanisms
Our goals are to identify the transcriptional and epigenetic networks that govern cardiomyocyte dedifferentiation and proliferation during regeneration. These studies could aid in converting adult cardiomyocytes to a more proliferative and regenerative state. In addition, we aim to identify the microenvironment signals that regulate mammalian heart regeneration by studying the interplay of nerves as well as extracellular factors during mammalian heart regeneration. We use multidisciplinary approaches including genomics, proteomics, and mouse genetics in addition to molecular and cellular technologies to address these questions.