Biology of the prostate gland at the molecular level
4111 Rennebohm Hall
777 Highland Ave
Madison, WI 53705
Cancer Biology; Developmental Biology & Regenerative Medicine
Research in my laboratory focuses on understanding the biology of the prostate gland at the molecular level. Interest in understanding the biology of the prostate is driven both by the fascinating nature of the developmental processes that function during organogenesis of the prostate and by the high incidence in humans of prostatic diseases including prostatic adenocarcinoma and benign prostatic hyperplasia. My laboratory is particularly interested in the role of intercellular communication between epithelial and mesenchymal/stromal cells during prostatic branching morphogenesis and during the progression of prostate cancer. We use a variety of approaches including techniques of cell and molecular biology as well as mouse genetics to study the roles of several growth factor signaling pathways in these processes. Currently, our efforts include detailed studies of components of FGF, WNT, and cyclic AMP pathways that we have implicated in developmental and/or pathological signaling events in the prostate gland.