Shigeki Miyamoto
Credentials: Oncology Department
Position title: Regulatory mechanisms of Rel/NF-kappaB transcription factors
Email: smiyamot@wisc.edu
Phone: (608) 262-9281
Address:
6159 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
LAB WEBSITE:
https://mcardle.wisc.edu/faculty-draft-jenny/shigeki-miyamoto/
FOCUS GROUPS:
Cancer Biology; Immunology; Transcriptional Mechanisms
RESEARCH DESCRIPTION:
We study regulation of the nuclear factor kappaB (NF-kB) family of transcription factors by extracellular stimuli. In particular we study the roles and activation mechanisms of NF-kB by genotoxic stress agents using cultured cell systems and in vivo genetically modified mouse models. We also study the role and regulation of NF-kB in B cell development and B cell malignancies, in particular multiple myeloma. We use biochemical, molecular and cellular approaches as well as knockout and knockin mouse models to study these processes.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Cancer Biology, Molecular and Cellular Pharmacology (MCP)