Shigeki Miyamoto

Oncology Department

Regulatory mechanisms of Rel/NF-kappaB transcription factors

smiyamot@wisc.edu

(608) 262-9281

6159 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705

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lab website:

https://mcardle.wisc.edu/who-we-are/mcardle-faculty/shigeki-miyamoto-phd

focus groups:

Cancer Biology; Immunology; Transcriptional Mechanisms

research description:

We study regulation of the nuclear factor kappaB (NF-kB) family of transcription factors by extracellular stimuli. In particular we study the roles and activation mechanisms of NF-kB by genotoxic stress agents using cultured cell systems and in vivo genetically modified mouse models. We also study the role and regulation of NF-kB in B cell development and B cell malignancies, in particular multiple myeloma. We use biochemical, molecular and cellular approaches as well as knockout and knockin mouse models to study these processes.

ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Cancer Biology, Molecular and Cellular Pharmacology (MCP)

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