Regulatory mechanisms of Rel/NF-kappaB transcription factors
6159 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Cancer Biology; Immunology; Transcriptional Mechanisms
We study regulation of the nuclear factor kappaB (NF-kB) family of transcription factors by extracellular stimuli. In particular we study the roles and activation mechanisms of NF-kB by genotoxic stress agents using cultured cell systems and in vivo genetically modified mouse models. We also study the role and regulation of NF-kB in B cell development and B cell malignancies, in particular multiple myeloma. We use biochemical, molecular and cellular approaches as well as knockout and knockin mouse models to study these processes.