Mitochondrial biogenesis and metabolism; cell signaling; proteomics
441 B Biochemistry
433 Babcock Dr
Madison, WI 53706
Cellular & Molecular Metabolism; Membrane Biology & Protein Trafficking; Systems Biology
Mitochondria house an array of biochemical pathways and are central to apoptosis and reactive oxygen species production. Cells need clever mechanisms to construct and control their mitochondria, and dysfunction of these organelles underlies a broad set of human diseases. By integrating classic biochemistry, molecular biology and genetics with large-scale proteomics and systems approaches we investigate how cells regulate their mitochondrial form and function across tissues and in response to a changing external environment. We also investigate the role of post-translational modifications in controlling mitochondrial protein function, and explore the biochemical functions of uncharacterized mitochondrial proteins implicated in human diseases.