Credentials: My research is based in immuno-oncology as an approach to develop curative treatments for common childhood cancers. Innate immune effector cells have an inherent ability to kill virally infected and transformed-malignant cells. This ability is diminished in the hostile tumor microenvironment due to multitude of factors such as exhaustion and deactivation via tumor ligands and cytokines. I work with natural killer cells (NK cells) of the innate immune system. I stimulate NK cells to increase cytotoxicity, and develop NK cell-based combination treatments. I accomplish this by using mouse models of bone marrow transplant to explore the between NK cells and other tumor-infiltrating lymphocytes, in addition to testing the efficacy of new therapies.
Class of 2018