Jayshree Samanta
Credentials: Comparative Biosciences
Position title: Remyelination by adult neural stem cells in the mouse brain
Email: jsamanta@wisc.edu
Phone: 608-262-4686
Address:
SVM 3354C
2015 Linden Dr.
Madison, WI 53706
LAB WEBSITE:
https://samantalab.vetmed.wisc.edu/
FOCUS GROUPS:
Cell Adhesion & Cytoskeleton; Developmental Biology & Regenerative Medicine; Transcriptional Mechanisms
RESEARCH DESCRIPTION:
The myelin sheath is a specialized cellular process of an oligodendrocyte, which spirally wraps around the axons of neurons in the vertebrate brain. In demyelinating diseases, disruption of myelin results in severe neurological defects due to conduction block ultimately leading to the loss of axons. Demyelination is a common feature in many neurological diseases including Multiple Sclerosis, Alzheimer’s disease and Schizophrenia.
The Samanta lab focuses on understanding the cellular and molecular mechanisms of regeneration of myelin from neural stem cells in the adult brain i.e. remyelination. Our primary goal is to understand the disease process and identify factors that can help neural stem cells repair the brain in demyelinating disorders, using in vivo disease models and in vitro cultures of adult neural stem cells.