Credentials: Dermatology Department
Position title: Cell and molecular biology of skin in health and disease
Phone: (608) 263-5362
439 Medical Sciences Center
1300 University Ave
Madison, WI 53706
Cancer Biology; Transcriptional Mechanisms
My ongoing research is focused on understanding a) functions of BRAF signaling beyond its role in driving cellular proliferation. We are investigating the cross-talk between BRAF and Notch signaling in affecting tumor cell differentiation and regulating cellular autophagy via the mTOR signaling pathway, b) calcium homeostasis in normal melanocytes and melanoma cells and the role of tissue-specific calcium channels of the transient receptor potential family proteins in melanoma tumor progression and c) potential and limitations of reprogrammed adult fibroblasts to generate structurally and functionally intact skin.