Stress regulation of cytokine production
Box 4108 Clinical Science Center
600 Highland Ave
Madison, WI 53792
There are three ongoing projects in the lab: 1) Dissecting the mechanisms by which the endoplasmic reticulum stress response the “Unfolded Protein Response” (UPR) support intracellular infection by Brucella melitensis. A related study is ongoing to understand defective generation of immunologic memory. 2) Analysis of genetics and related functional alterations in inflammatory cytokine production by macrophages from spondyloarthritis patients. 3) Determining the role of the asthma risk gene ORMDL3 in shaping UPR and altered immune responses.