The image depicts interconnected metabolic pathways and highlights mitochondria as a central hub in cellular metabolism.

The image depicts interconnected metabolic pathways and highlights mitochondria as a central hub in cellular metabolism.
(Figure by Amy Lin)

Cellular and Molecular Metabolism

In recent years, there has been a resurgence of interest in metabolism and an appreciation for its central role in wide range of cellular and molecular process.  Metabolic disorders including obesity, diabetes, hypertension and atherosclerotic heart disease are among the most prominent and costly conditions affecting people worldwide. It is becoming clear that these and other common diseases such as cancer and neurodegenerative disorders, result from alterations in both classic and newly defined metabolic pathways. Researches in the Cellular and Molecular Metabolism focus group are leveraging a wide array of techniques, ranging from mass spectrometry-based proteomics and metabolomics to organismal physiology and genetics, to explore these problems and their molecular underpinnings.

Headshot

Focus Group Chair Dudley Lamming
Medicine Department
Regulation of metabolism by nutrient signaling pathways
lamming@wisc.edu

Focus Group Members

Caroline Alexander

Credentials: Oncology Department

Position title: Mammary tumor cell biology

Email: alexander@oncology.wisc.edu

Rozalyn Anderson

Credentials: Medicine Department

Position title: Metabolism of aging and age-related disease

Email: rozalyn.anderson@wisc.edu

Alan Attie

Credentials: Biochemistry Department

Position title: Molecular genetics of diabetes & insulin resistance; cell biology of lipoprotein assembly, cholesterol trafficking

Email: adattie@wisc.edu

Barak Blum

Credentials: Cell & Regenerative Biology Department

Position title: Functional beta cell maturation

Email: bblum4@wisc.edu

Jacob Brunkard

Credentials: Genetics Department

Position title: Molecular mechanisms regulating plant metabolism

Email: brunkard@wisc.edu

Jason Cantor

Credentials: Biochemistry Department

Position title: Influence of environmental factors on human cell metabolism

Email: jcantor@morgridge.org

Vincent Cryns

Credentials: Medicine Department

Position title: Mechanisms of cell death in disease

Email: vlcryns@medicine.wisc.edu

Dawn Davis

Credentials: Medicine, Division of Endocrinology

Position title: Pancreatic islet biology

Email: dbd@medicine.wisc.edu

Loren Denlinger

Credentials: Medicine Department

Position title: Pathogen-host interactions important to airway inflammation

Email: ldenling@wisc.edu

John Denu

Credentials: Biomolecular Chemistry Department

Position title: Mechanisms of chromatin dynamics, epigenetics, metabolism, and signaling

Email: jmdenu@wisc.edu

Joseph Dillard

Credentials: Medical Microbiology & Immunology Department

Position title: Bacterial pathogenesis

Email: jpdillard@wisc.edu

Timothy Donohue

Credentials: Bacteriology Department

Position title: Process & control of bioenergy generation

Email: tdonohue@bact.wisc.edu

Richard Eisenstein

Credentials: Nutritional Sciences Department

Position title: Molecular control of vertebrate iron metabolism

Email: eisenste@nutrisci.wisc.edu

Feyza Engin

Credentials: Biomolecular Chemistry Department

Position title: Endoplasmic reticulum stress, organelle dysfunction, unfolded protein response, beta cell function and diabetes

Email: fengin@wisc.edu

Jing Fan

Credentials: Nutritional Sciences Department

Position title: Mammalian cellular metabolism; metabolic regulation; tumor microenvironment

Email: jfan4@wisc.edu

Daniel Greenspan

Credentials: Cell & Regenerative Biology Department

Position title: Extracellular modulators of cellular behavior

Email: dsgreens@wisc.edu

Troy Hornberger

Credentials: Comparative Biosciences Department

Position title: Mechanotransduction and the regulation of skeletal muscle mass

Email: troy.hornberger@wisc.edu

Andrew Hryckowian

Credentials: Medicine and Medical Microbiology & Immunology Department

Position title: Molecular mechanisms of microbiome dynamics

Email: Hryckowian@medicine.wisc.edu

Tu-Anh Huynh

Credentials: Food Science Department

Position title: C-di-AMP signaling in bacterial physiology and pathogenesis

Email: thuynh6@wisc.edu

Nancy Keller

Credentials: Medical Microbiology & Immunology Department

Position title: Aspergillus cell biology

Email: npkeller@wisc.edu

Patricia Kiley

Credentials: Biomolecular Chemistry Department

Position title: Molecular genetics and biochemistry of oxygen regulated gene expression and transcription activation

Email: pjkiley@wisc.edu

Michelle Kimple

Credentials: Medicine Department

Position title: Regulation of pancreatic beta-cell biology

Email: mkimple@medicine.wisc.edu

Adam Konopka

Credentials: Medicine Department

Position title: Musculoskeletal aging and metabolism

Email: akonopka@medicine.wisc.edu

Hiroshi Maeda

Credentials: Botany Department

Position title: Amino acid homeostasis in plants

Email: maeda2@wisc.edu

Ahmed Mahmoud

Credentials: Cell & Regenerative Biology Department

Position title: Mammalian Heart Regeneration

Email: aimahmoud@wisc.edu

Mark Mandel

Credentials: Medical Microbiology & Immunology Department

Position title: Genetic analysis of bacterial colonization

Email: mmandel@wisc.edu

Thomas Martin

Credentials: Biochemistry Department

Position title: Mechanisms of hormone action; regulation of hormone/neurotransmitter secretion

Email: tfmartin@wisc.edu

Matthew Merrins

Credentials: Medicine Department

Position title: Beta cell biology and diabetes

Email: merrins@wisc.edu

Freya Mowat

Credentials: Ophthalmology and Visual Sciences Department

Position title: Retinal photoreceptor metabolism and aging

Email: mowat@wisc.edu

Jon Odorico

Credentials: Surgery Department

Position title: Embryonic stem cells to generate insulin producing cells for the treatment of diabetes and to study pancreatic islet development

Email: jon@surgery.wisc.edu

Luigi Puglielli

Credentials: Medicine Department

Position title: Molecular mechanisms of neurodevelopment and neurodegeneration

Email: lp1@medicine.wisc.edu

Avtar Roopra

Credentials: Neuroscience Department

Position title: Regulation of chromatin structure in neurons and cancer

Email: asroopra@wisc.edu

Nader Sheibani

Credentials: Ophthalmology & Visual Sciences Department

Position title: Cell adhesion and signaling in vascular cells

Email: nsheibanikar@wisc.edu

Judith Simcox

Credentials: Biochemistry Department

Position title: Lipid metabolism in cold exposure

Email: jsimcox@wisc.edu

Melissa Skala

Credentials: Biomedical Engineering Department

Position title: Metabolism, cancer, microscopy

Email: mcskala@wisc.edu

John Svaren

Credentials: Comparative Biosciences Department

Position title: Transcriptional regulation of peripheral nerve myelination

Email: jpsvaren@wisc.edu

Randal Tibbetts

Credentials: Human Oncology Department

Position title: DNA repair; gene expression; neurodegeneration; amyotrophic lateral sclerosis

Email: rstibbetts@wisc.edu

Jade Wang

Credentials: Stress and genome integrity in bacteria

Position title: Stress and genome integrity in bacteria

Email: wang@bact.wisc.edu

David Wassarman

Credentials: Medical Genetics Department

Position title: Neurodegeneration in Drosophila

Email: dawassarman@wisc.edu

Wei Xu

Credentials: Oncology Department

Position title: Epigenetic regulation of breast cancer

Email: wxu@oncology.wisc.edu