The image depicts interconnected metabolic pathways and highlights mitochondria as a central hub in cellular metabolism.

The image depicts interconnected metabolic pathways and highlights mitochondria as a central hub in cellular metabolism.
(Figure by Amy Lin)

Cellular and Molecular Metabolism

In recent years, there has been a resurgence of interest in metabolism and an appreciation for its central role in wide range of cellular and molecular process.  Metabolic disorders including obesity, diabetes, hypertension and atherosclerotic heart disease are among the most prominent and costly conditions affecting people worldwide. It is becoming clear that these and other common diseases such as cancer and neurodegenerative disorders, result from alterations in both classic and newly defined metabolic pathways. Researches in the Cellular and Molecular Metabolism focus group are leveraging a wide array of techniques, ranging from mass spectrometry-based proteomics and metabolomics to organismal physiology and genetics, to explore these problems and their molecular underpinnings.

Headshot

Focus Group Chair Dudley Lamming
Medicine Department
Regulation of metabolism by nutrient signaling pathways
lamming@wisc.edu

Focus Group Members

Caroline Alexander

Credentials: Oncology Department

Position title: Skin and metabolic physiology

Email: alexander@oncology.wisc.edu

Rozalyn Anderson

Credentials: Medicine Department

Position title: Metabolism of aging and age-related disease

Email: rozalyn.anderson@wisc.edu

Alan Attie

Credentials: Biochemistry Department

Position title: Molecular genetics of diabetes & insulin resistance; cell biology of lipoprotein assembly, cholesterol trafficking

Email: adattie@wisc.edu

Barak Blum

Credentials: Cell & Regenerative Biology Department

Position title: Functional beta cell maturation

Email: bblum4@wisc.edu

Jacob Brunkard

Credentials: Genetics Department

Position title: Molecular mechanisms regulating plant metabolism

Email: brunkard@wisc.edu

Jason Cantor

Credentials: Biochemistry Department

Position title: Influence of environmental factors on human cell metabolism

Email: jcantor@morgridge.org

Josh Coon

Credentials: Biomolecular Chemistry

Position title: Systems and quantitative biology

Email: jcoon@chem.wisc.edu

Vincent Cryns

Credentials: Medicine Department

Position title: Mechanisms of cell death in disease

Email: vlcryns@medicine.wisc.edu

Dawn Davis

Credentials: Medicine, Division of Endocrinology

Position title: Pancreatic islet biology

Email: dbd@medicine.wisc.edu

John Denu

Credentials: Biomolecular Chemistry Department

Position title: Mechanisms of chromatin dynamics, epigenetics, metabolism, and signaling

Email: jmdenu@wisc.edu

Timothy Donohue

Credentials: Bacteriology Department

Position title: Process & control of bioenergy generation

Email: tdonohue@bact.wisc.edu

Daniela Drummond Barbosa

Credentials: Genetics

Position title: Physiology of stem cell lineages

Email: ddbarbosa@wisc.edu

Lee Eckhardt

Credentials: Medicine Department

Position title: Functional genomics approach to understand cardiac-arrhythmia

Email: lle@medicine.wisc.edu

Feyza Engin

Credentials: Biomolecular Chemistry Department

Position title: Endoplasmic reticulum stress, organelle dysfunction, unfolded protein response, beta cell function and diabetes

Email: fengin@wisc.edu

Jing Fan

Credentials: Nutritional Sciences Department

Position title: Mammalian cellular metabolism; metabolic regulation; tumor microenvironment

Email: jfan4@wisc.edu

Andrea Galmozzi

Credentials: Medicine Department

Position title: Intracellular trafficking of signaling metabolites

Email: agalmozzi@medicine.wisc.edu

Wei Guo

Credentials: Animal Health & Biomedical Sciences

Position title: Muscle Structure and Function, RNA Biology

Email: wguo2@wisc.edu

Troy Hornberger

Credentials: Comparative Biosciences Department

Position title: Mechanotransduction and the regulation of skeletal muscle mass

Email: troy.hornberger@wisc.edu

Andrew Hryckowian

Credentials: Medicine and Medical Microbiology & Immunology Department

Position title: Molecular mechanisms of microbiome dynamics

Email: Hryckowian@medicine.wisc.edu

Tu-Anh Huynh

Credentials: Food Science Department

Position title: C-di-AMP signaling in bacterial physiology and pathogenesis

Email: thuynh6@wisc.edu

Jiaoyang Jiang

Credentials: Pharmaceutical Sciences

Position title: Protein glycosylation in biology and disease

Email: jiaoyang.jiang@wisc.edu

Mehdi Kabbage

Credentials: Plant Pathology Department

Position title: Programmed Cell Death/Host-Microbe Interactions

Email: kabbage@wisc.edu

Nancy Keller

Credentials: Medical Microbiology & Immunology Department

Position title: Fungi, secondary metabolism, pathogenesis

Email: npkeller@wisc.edu

Michelle Kimple

Credentials: Medicine Department

Position title: GPCRs in pancreatic islet biology

Email: mkimple@medicine.wisc.edu

Adam Konopka

Credentials: Medicine Department

Position title: Musculoskeletal aging and metabolism

Email: akonopka@medicine.wisc.edu

Hiroshi Maeda

Credentials: Botany Department

Position title: Amino acid homeostasis in plants

Email: maeda2@wisc.edu

Ahmed Mahmoud

Credentials: Cell & Regenerative Biology Department

Position title: Mammalian Heart Regeneration

Email: aimahmoud@wisc.edu

Mark Mandel

Credentials: Medical Microbiology & Immunology Department

Position title: Genetic analysis of bacterial colonization

Email: mmandel@wisc.edu

Thomas Martin

Credentials: Biochemistry Department

Position title: Mechanisms of hormone action; regulation of hormone/neurotransmitter secretion

Email: tfmartin@wisc.edu

Sara McCoy

Credentials: Medicine Department

Position title: Mesenchymal stromal cell immunobiology

Email: ssmccoy@medicine.wisc.edu

Matthew Merrins

Credentials: Medicine

Position title: Beta cell biology and diabetes

Email: merrins@wisc.edu

Mark Meyer

Credentials: Nutritional Sciences Department

Position title: Investigating genomic mechanisms of transcription, metabolism, and disease progression

Email: markmeyer@wisc.edu

Freya Mowat

Credentials: Ophthalmology and Visual Sciences Department

Position title: Retinal photoreceptor metabolism and aging

Email: mowat@wisc.edu

Jon Odorico

Credentials: Surgery Department

Position title: Embryonic stem cells to generate insulin producing cells for the treatment of diabetes and to study pancreatic islet development

Email: jon@surgery.wisc.edu

Brian Parks

Credentials: Nutritional Sciences Department

Position title: Causal genes of metabolic diseases

Email: brian.w.parks@wisc.edu

Bret Payseur

Credentials: Genetics

Position title: Evolution of extreme phenotypes

Email: payseur@wisc.edu

Luigi Puglielli

Credentials: Medicine Department

Position title: Molecular mechanisms of neurodevelopment and neurodegeneration

Email: lp1@medicine.wisc.edu

Timothy Rhoads

Credentials: Nutritional Sciences Department

Position title: Gene expression regulation of metabolism and aging

Email: timothy.rhoads@wisc.edu

Claire Richardson

Credentials: Genetics

Position title: Cellular & molecular neurobiology, aging

Email: Claire.richardson@wisc.edu

Abbas Rizvi

Credentials: Neuroscience Department

Position title: Single cell and spatially resolved studies of gene regulation

Email: ahrizvi@wisc.edu

Avtar Roopra

Credentials: Neuroscience Department

Position title: Regulation of chromatin structure in neurons and cancer

Email: asroopra@wisc.edu

Nader Sheibani

Credentials: Ophthalmology & Visual Sciences Department

Position title: Cell adhesion and signaling in vascular cells

Email: nsheibanikar@wisc.edu

Judith Simcox

Credentials: Biochemistry Department

Position title: Lipid metabolism in cold exposure

Email: jsimcox@wisc.edu

Melissa Skala

Credentials: Biomedical Engineering Department

Position title: Metabolism, cancer, microscopy

Email: mcskala@wisc.edu

John Svaren

Credentials: Comparative Biosciences Department

Position title: Transcriptional regulation of peripheral nerve myelination

Email: jpsvaren@wisc.edu

Randal Tibbetts

Credentials: Human Oncology Department

Position title: DNA repair; gene expression; neurodegeneration; amyotrophic lateral sclerosis

Email: rstibbetts@wisc.edu

Marcelo Vargas

Credentials: Neurology Department

Position title: Cell and molecular biology of astrocytes. Amyotrophic lateral sclerosis.

Email: mvargas@wisc.edu

Jade Wang

Credentials: Bacteriology Department

Position title: Stress and genome integrity in bacteria

Email: wang@bact.wisc.edu

David Wassarman

Credentials: Medical Genetics Department

Position title: Neurodegeneration in Drosophila

Email: dawassarman@wisc.edu

Wei Xu

Credentials: Oncology Department

Position title: Epigenetic regulation of breast cancer

Email: wxu@oncology.wisc.edu