In recent years, there has been a resurgence of interest in metabolism and an appreciation for its central role in wide range of cellular and molecular process. Metabolic disorders including obesity, diabetes, hypertension and atherosclerotic heart disease are among the most prominent and costly conditions affecting people worldwide. It is becoming clear that these and other common diseases such as cancer and neurodegenerative disorders, result from alterations in both classic and newly defined metabolic pathways. Researches in the Cellular and Molecular Metabolism focus group are leveraging a wide array of techniques, ranging from mass spectrometry-based proteomics and metabolomics to organismal physiology and genetics, to explore these problems and their molecular underpinnings.
Focus Group Chair David Pagliarini
Biochemistry Department
Mitochondrial biogenesis and metabolism; cell signaling; proteomics
pagliarini@wisc.edu
Focus Group Members
Alan Attie
Biochemistry Department
Molecular genetics of diabetes & insulin resistance; cell biology of lipoprotein assembly, cholesterol trafficking
John Denu
Biomolecular Chemistry Department
Mechanisms of chromatin dynamics, epigenetics, metabolism, and signaling
Feyza Engin
Biomolecular Chemistry Department
Endoplasmic reticulum stress, organelle dysfunction, unfolded protein response, beta cell function and diabetes
Jing Fan
Nutritional Sciences Department
Mammalian cellular metabolism; metabolic regulation; tumor microenvironment
Daniel Greenspan
Cell & Regenerative Biology Department
Extracellular modulators of cellular behavior
Troy Hornberger
Comparative Biosciences Department
Mechanotransduction and the regulation of skeletal muscle mass
Patricia Kiley
Biomolecular Chemistry Department
Molecular genetics and biochemistry of oxygen regulated gene expression and transcription activation
Thomas Martin
Biochemistry Department
Mechanisms of hormone action; regulation of hormone/neurotransmitter secretion
Jon Odorico
Surgery Department
Embryonic stem cells to generate insulin producing cells for the treatment of diabetes and to study pancreatic islet development
Nader Sheibani
Ophthalmology & Visual Sciences Department
Cell adhesion and signaling in vascular cells
Randal Tibbetts
Human Oncology Department
DNA repair; gene expression; neurodegeneration; amyotrophic lateral sclerosis
