In recent years, there has been a resurgence of interest in metabolism and an appreciation for its central role in wide range of cellular and molecular process. Metabolic disorders including obesity, diabetes, hypertension and atherosclerotic heart disease are among the most prominent and costly conditions affecting people worldwide. It is becoming clear that these and other common diseases such as cancer and neurodegenerative disorders, result from alterations in both classic and newly defined metabolic pathways. Researches in the Cellular and Molecular Metabolism focus group are leveraging a wide array of techniques, ranging from mass spectrometry-based proteomics and metabolomics to organismal physiology and genetics, to explore these problems and their molecular underpinnings.
Focus Group Chair Dudley Lamming
Medicine Department
Regulation of metabolism by nutrient signaling pathways
lamming@wisc.edu
Focus Group Members
Caroline Alexander
Credentials: Oncology Department
Position title: Mammary tumor cell biology
Email: alexander@oncology.wisc.edu
Rozalyn Anderson
Credentials: Medicine Department
Position title: Metabolism of aging and age-related disease
Email: rozalyn.anderson@wisc.edu
Alan Attie
Credentials: Biochemistry Department
Position title: Molecular genetics of diabetes & insulin resistance; cell biology of lipoprotein assembly, cholesterol trafficking
Email: adattie@wisc.edu
Barak Blum
Credentials: Cell & Regenerative Biology Department
Position title: Functional beta cell maturation
Email: bblum4@wisc.edu
Jacob Brunkard
Credentials: Genetics Department
Position title: Molecular mechanisms regulating plant metabolism
Email: brunkard@wisc.edu
Jason Cantor
Credentials: Biochemistry Department
Position title: Influence of environmental factors on human cell metabolism
Email: jcantor@morgridge.org
Vincent Cryns
Credentials: Medicine Department
Position title: Mechanisms of cell death in disease
Email: vlcryns@medicine.wisc.edu
Dawn Davis
Credentials: Medicine, Division of Endocrinology
Position title: Pancreatic islet biology
Email: dbd@medicine.wisc.edu
Loren Denlinger
Credentials: Medicine Department
Position title: Pathogen-host interactions important to airway inflammation
Email: ldenling@wisc.edu
John Denu
Credentials: Biomolecular Chemistry Department
Position title: Mechanisms of chromatin dynamics, epigenetics, metabolism, and signaling
Email: jmdenu@wisc.edu
Joseph Dillard
Credentials: Medical Microbiology & Immunology Department
Position title: Bacterial pathogenesis
Email: jpdillard@wisc.edu
Timothy Donohue
Credentials: Bacteriology Department
Position title: Process & control of bioenergy generation
Email: tdonohue@bact.wisc.edu
Richard Eisenstein
Credentials: Nutritional Sciences Department
Position title: Molecular control of vertebrate iron metabolism
Email: eisenste@nutrisci.wisc.edu
Feyza Engin
Credentials: Biomolecular Chemistry Department
Position title: Endoplasmic reticulum stress, organelle dysfunction, unfolded protein response, beta cell function and diabetes
Email: fengin@wisc.edu
Jing Fan
Credentials: Nutritional Sciences Department
Position title: Mammalian cellular metabolism; metabolic regulation; tumor microenvironment
Email: jfan4@wisc.edu
Daniel Greenspan
Credentials: Cell & Regenerative Biology Department
Position title: Extracellular modulators of cellular behavior
Email: dsgreens@wisc.edu
Troy Hornberger
Credentials: Comparative Biosciences Department
Position title: Mechanotransduction and the regulation of skeletal muscle mass
Email: troy.hornberger@wisc.edu
Andrew Hryckowian
Credentials: Medicine and Medical Microbiology & Immunology Department
Position title: Molecular mechanisms of microbiome dynamics
Email: Hryckowian@medicine.wisc.edu
Tu-Anh Huynh
Credentials: Food Science Department
Position title: C-di-AMP signaling in bacterial physiology and pathogenesis
Email: thuynh6@wisc.edu
Nancy Keller
Credentials: Medical Microbiology & Immunology Department
Position title: Aspergillus cell biology
Email: npkeller@wisc.edu
Patricia Kiley
Credentials: Biomolecular Chemistry Department
Position title: Molecular genetics and biochemistry of oxygen regulated gene expression and transcription activation
Email: pjkiley@wisc.edu
Michelle Kimple
Credentials: Medicine Department
Position title: Regulation of pancreatic beta-cell biology
Email: mkimple@medicine.wisc.edu
Adam Konopka
Credentials: Medicine Department
Position title: Musculoskeletal aging and metabolism
Email: akonopka@medicine.wisc.edu
Hiroshi Maeda
Credentials: Botany Department
Position title: Amino acid homeostasis in plants
Email: maeda2@wisc.edu
Ahmed Mahmoud
Credentials: Cell & Regenerative Biology Department
Position title: Mammalian Heart Regeneration
Email: aimahmoud@wisc.edu
Mark Mandel
Credentials: Medical Microbiology & Immunology Department
Position title: Genetic analysis of bacterial colonization
Email: mmandel@wisc.edu
Thomas Martin
Credentials: Biochemistry Department
Position title: Mechanisms of hormone action; regulation of hormone/neurotransmitter secretion
Email: tfmartin@wisc.edu
Matthew Merrins
Credentials: Medicine Department
Position title: Beta cell biology and diabetes
Email: merrins@wisc.edu
Freya Mowat
Credentials: Ophthalmology and Visual Sciences Department
Position title: Retinal photoreceptor metabolism and aging
Email: mowat@wisc.edu
Jon Odorico
Credentials: Surgery Department
Position title: Embryonic stem cells to generate insulin producing cells for the treatment of diabetes and to study pancreatic islet development
Email: jon@surgery.wisc.edu
Luigi Puglielli
Credentials: Medicine Department
Position title: Molecular mechanisms of neurodevelopment and neurodegeneration
Email: lp1@medicine.wisc.edu
Avtar Roopra
Credentials: Neuroscience Department
Position title: Regulation of chromatin structure in neurons and cancer
Email: asroopra@wisc.edu
Nader Sheibani
Credentials: Ophthalmology & Visual Sciences Department
Position title: Cell adhesion and signaling in vascular cells
Email: nsheibanikar@wisc.edu
Judith Simcox
Credentials: Biochemistry Department
Position title: Lipid metabolism in cold exposure
Email: jsimcox@wisc.edu
Melissa Skala
Credentials: Biomedical Engineering Department
Position title: Metabolism, cancer, microscopy
Email: mcskala@wisc.edu
John Svaren
Credentials: Comparative Biosciences Department
Position title: Transcriptional regulation of peripheral nerve myelination
Email: jpsvaren@wisc.edu
Randal Tibbetts
Credentials: Human Oncology Department
Position title: DNA repair; gene expression; neurodegeneration; amyotrophic lateral sclerosis
Email: rstibbetts@wisc.edu
Jade Wang
Credentials: Stress and genome integrity in bacteria
Position title: Stress and genome integrity in bacteria
Email: wang@bact.wisc.edu
David Wassarman
Credentials: Medical Genetics Department
Position title: Neurodegeneration in Drosophila
Email: dawassarman@wisc.edu
Wei Xu
Credentials: Oncology Department
Position title: Epigenetic regulation of breast cancer
Email: wxu@oncology.wisc.edu