University of Wisconsin–Madison
The image depicts interconnected metabolic pathways and highlights mitochondria as a central hub in cellular metabolism.

The image depicts interconnected metabolic pathways and highlights mitochondria as a central hub in cellular metabolism.
(Figure by Amy Lin)

Cellular and Molecular Metabolism

In recent years, there has been a resurgence of interest in metabolism and an appreciation for its central role in wide range of cellular and molecular process.  Metabolic disorders including obesity, diabetes, hypertension and atherosclerotic heart disease are among the most prominent and costly conditions affecting people worldwide. It is becoming clear that these and other common diseases such as cancer and neurodegenerative disorders, result from alterations in both classic and newly defined metabolic pathways. Researches in the Cellular and Molecular Metabolism focus group are leveraging a wide array of techniques, ranging from mass spectrometry-based proteomics and metabolomics to organismal physiology and genetics, to explore these problems and their molecular underpinnings.

Headshot

Focus Group Chair David Pagliarini
Biochemistry Department
Mitochondrial biogenesis and metabolism; cell signaling; proteomics
pagliarini@wisc.edu

Focus Group Members

Caroline Alexander

Oncology Department

Mammary tumor cell biology

alexander@oncology.wisc.edu

Alan Attie

Biochemistry Department

Molecular genetics of diabetes & insulin resistance; cell biology of lipoprotein assembly, cholesterol trafficking

adattie@wisc.edu

Barak Blum

Cell & Regenerative Biology Department

Functional beta cell maturation

bblum4@wisc.edu

Vincent Cryns

Medicine Department

Mechanisms of cell death in disease

vlcryns@medicine.wisc.edu

Loren Denlinger

Medicine Department

Pathogen-host interactions important to airway inflammation

ldenling@wisc.edu

John Denu

Biomolecular Chemistry Department

Mechanisms of chromatin dynamics, epigenetics, metabolism, and signaling

jmdenu@wisc.edu

Joseph Dillard

Medical Microbiology & Immunology Department

Bacterial pathogenesis

jpdillard@wisc.edu

Timothy Donohue

Bacteriology Department

Process & control of bioenergy generation

tdonohue@bact.wisc.edu

Richard Eisenstein

Nutritional Sciences Department

Molecular control of vertebrate iron metabolism

eisenste@nutrisci.wisc.edu

Feyza Engin

Biomolecular Chemistry Department

The role of organelle dysfunction and stress responses in the pathogenesis of diabetes

fengin@wisc.edu

Jing Fan

Nutritional Sciences Department

Mammalian cellular metabolism; metabolic regulation; tumor microenvironment

jfan4@wisc.edu

Daniel Greenspan

Cell & Regenerative Biology Department

Extracellular modulators of cellular behavior

dsgreens@wisc.edu

Troy Hornberger

Comparative Biosciences Department

Mechanotransduction and the regulation of skeletal muscle mass

troy.hornberger@wisc.edu

Nancy Keller

Medical Microbiology & Immunology Department

Aspergillus cell biology

npkeller@wisc.edu

Patricia Kiley

Biomolecular Chemistry Department

Molecular genetics and biochemistry of oxygen regulated gene expression and transcription activation

pjkiley@wisc.edu

Michelle Kimple

Medicine Department

Regulation of pancreatic beta-cell biology

mkimple@medicine.wisc.edu

Dudley Lamming

Medicine Department

Regulation of metabolism by nutrient signaling pathways

lamming@wisc.edu

Matthew Merrins

Medicine Department

Beta cell biology and diabetes

merrins@wisc.edu

Brian Pfleger

Chemical & Biological Engineering Department

Sustainability through synthetic biology

pfleger@engr.wisc.edu

Luigi Puglielli

Medicine Department

Molecular mechanisms of neurodevelopment and neurodegeneration

lp1@medicine.wisc.edu

Philip Romero

Biochemistry Department

Protein engineering

promero2@wisc.edu

Nader Sheibani

Opthalmology & Visual Sciences Department

Cell adhesion and signaling in vascular cells

nsheibanikar@wisc.edu

Melissa Skala

Biomedical Engineering Department

Metabolism, cancer, microscopy

mcskala@wisc.edu

Randal Tibbetts

Human Oncology Department

DNA repair; gene expression; neurodegeneration; amyotrophic lateral sclerosis

rstibbetts@wisc.edu

Jade Wang

Stress and genome integrity in bacteria

Stress and genome integrity in bacteria

wang@bact.wisc.edu