Student Spotlight: Nick Arp


Eldridge, Iowa

Year entered CMB program:



Jing Fan Lab


Brief Summary of Research:

I study the dynamic reprogramming of macrophage metabolism and how it relates to immune cell function.

Awards and Publications:

Arp NL, Seim GL, Votava JA, Josephson J, Fan J. Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism. J Biol Chem. 2023 Oct 10:105333. doi: 10.1016/j.jbc.2023.105333. Epub ahead of print. PMID: 37827290.

Seim GL, John SV, Arp NL, Fang Z, Pagliarini DJ, Fan J. Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases. Nat Chem Biol. 2023 Mar;19(3):265-274. doi: 10.1038/s41589-022-01153-w. Epub 2022 Oct 20. PMID: 36266351; PMCID: PMC9974485.

Why did you choose UW-Madison’s CMB Program?

I chose CMB because of its large pool of potential faculty with a wide-range of research interests, which this was helpful when trying to find a thesis advisor/mentor.

What lessons have you learned throughout your graduate career so far?

Mentorship is key throughout the graduate school experience and selecting a mentor is just as important as the topic of the research.

What are your long-term career goals?

My ultimate career goal as an academic physician-scientist is to provide clinical care for critically ill patients and explore immune cell metabolism dysregulation in human diseases.

When you are not in the lab, you are…….?

Sailing on Lake Mendota or going for a run!

What is the most fun part of your research?

It is exciting to be able to get hands-on training with liquid chromatography-mass spectrometry – from sample preparation to running the instrument to data analysis.