Credentials: Institute for Molecular Virology, Oncology, Plant Pathology Department
Position title: Virus Replication and Host Interactions
Phone: (608) 263-5916
841a Robert M Bock Lab
1525 Linden Dr
Madison, WI 53706
Virology; Molecular & Genome Biology of Microbes; Cancer Biology
Our laboratory studies the molecular mechanisms by which viruses replicate, interact with host cells, and promote tumor induction and maintenance. Our work spans fundamental studies in cell culture to translational studies with large collections of patient samples. The goals of these analyses are to advance understanding of virus infection and cell biology, and to use the results to prevent and treat virus infection and virus-induced tumors. To these ends, we focus on advanced models for the replication of positive-strand RNA viruses (which include the COVID-19 virus SARS-CoV-2 and many other pathogens); two cancer-relevant reverse-transcribing viruses, HIV-1 and hepatitis B virus; and the DNA tumor virus human papillomavirus (HPV), which causes over 5% of human cancers. Our research integrates molecular genetics, biochemistry, cell biology, cryo-EM and computational biology.