Mammary tumor cell biology
6505 WI Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Cancer Biology; Cellular & Molecular Metabolism; Physiology
Our lab studies the cellular and molecular interactions that determine the development of normal mammary gland and breast tumors. We apply a combination of in vitro and in vivo approaches to discover, examine and verify important molecular signaling processes. Specifically, current projects focus on 1) how a mammary stem cell marker, the Wnt co-receptor Lrp5, promotes glucose uptake critical to breast epithelial stem cells, and 2) how the heat transfer properties of skin modulate whole body metabolism, with the goal of evaluating whether the adjustment of skin properties can be used for tumor prevention.