Position title: Genetic diversity of microbial systems
Genetics-Biotechnology Center Building
425 Henry Mall
Madison, WI 53706
Membrane Biology & Protein Trafficking, Molecular & Genome Biology of Microbes, Systems Biology
Our work in molecular biology seeks to understand how diversity among genes and genomes contributes to altered function at the molecular and organismal level. While ~99% of the genetic diversity present on the planet arose from other genetic sequences, researchers have spent very little time investigating how gene families or sets of closely-related paralogs in the same species are functionally partitioned in early evolutionary events. We are focusing on a gene family expansion of a subunit of the major transcriptional complex Mediator to understand how transcription factors are affected by this process. Additionally, other work in the lab looks how larger scale intraspecies genetic diversity alters cellular behaviors and produces different measurable phenotypes. More specifically, this work looks at how changes to cellular responses and host cell interaction change colonization by Candida albicans strains.