Laboratory of Cell and Molecular Biology & Integrative Biology Department
Signal transduction, cell division, and cytoskeleton
335 Robert M Bock Lab
1525 Linden Dr
Madison, WI 53706
Cell Adhesion & Cytoskeleton; Developmental Biology & Regenerative Medicine
We seek to understand how cells build transient cytoskeletal structures at the right place and right time. Such structures include the cytokinetic apparatus (which pinches the cell in half) and the “wound array”, a cytoskeletal structure that forms around and closes over the sites of cell damage. In each case we are particularly interested in understanding how the relevant signals (ie for cytokinesis or cell repair) are generated and interpreted by the cell to result in the assembly and closure of the structure in question. We conceptualize these processes in terms of single cell pattern formation: in each case the cell somehow manages to develop a precise signaling pattern at the cell cortex and then converts this pattern into the appropriate structure.