Position title: Mechanisms regulating cancer progression
Medical Science Center
1300 University Avenue
Madison, WI 53706
Cancer Biology; Developmental Biology & Regenerative Medicine; Physiology
Our lab is committed to understand the mechanisms of impairment and failure of biological systems under pathological conditions, focusing on tissue stem cells, vasculature and the peripheral nervous system present in different tissues microenvironments, with emphasis on preventing or reversing these deleterious processes. We are interested in studying mechanisms that lead to cell behavior changes during development, throughout life and disease. Understanding how these mechanisms are affected in cancer will help develop targets for novel therapies. For this, we take advantage of state-of-the-art technologies, including two-photon and confocal microscopy, in vivo lineage-tracing methods, FACS-sorting, single-cell RNA sequencing, organ, tissue and cell transplantation, neural circuitry analysis, and sophisticated Cre/loxP techniques in combination with cancer mouse models. Thus, our ultimate goal is to identify novel potential cellular and molecular targets for cancer therapy.