Christian Capitini
Credentials: Pediatrics Department
Position title: Adoptive cell therapies (NK cell and CAR T cell infusions), Bone marrow transplant, GVHD
Email: ccapitini@pediatrics.wisc.edu
Phone: (608) 262-2415
Address:
Wi Institute Medical Research (WIMR) 4137
1111 Highland Ave
Madison, WI 53705
LAB WEBSITE:
FOCUS GROUPS:
Immunology; Cancer Biology
RESEARCH DESCRIPTION:
Dr. Capitini leads an NIH-supported laboratory focusing on development of cell-based therapies, including NK cells and CAR T cells, for the treatment of childhood cancers like neuroblastoma and osteosarcoma. The laboratory also manufactures cell-based therapies for complications of bone marrow transplant, including using exosomes to generate alternatively activated monocytes to treat graft-versus-host-disease and acute radiation syndrome.
In the clinic, Dr. Capitini was a site Principal Investigator (PI) for the first multicenter CAR T cell trial, which lead to the FDA approval of tisagenlecleucel-T (Kymriah). Presently he is a a Sponsor and PI of a clinical trial testing alpha/beta T
cell depleted stem cell transplant for high-risk childhood cancers using post-transplant zoledronate to activate gamma/delta T cells and NK cells, and is developing virus-free CRISPR-edited GD2 CAR T cells for first-in-human testing in adults and children with GD2+ solid tumors.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS:
Cellular and Molecular Pathology (CMP), ICTR, Comparative Biomedical Sciences (CBMS)