Exocytosis, synaptic transmission, neuronal cell biology
9557 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Membrane Biology & Protein Trafficking; Physiology
Our research is focused on understanding the structure, function and dynamics of the exocytotic membrane “fusion machine” that mediates the release of neurotransmitters and hormones from neurons. We study membrane fusion using approaches that range from reconstituted fusion assays to electrophysiological measurements of synaptic transmission in brain slices. We also study myriad additional aspects of polarized membrane traffic in neurons, the mechanism of action of the clostridial neurotoxins (tetanus and botulinum toxins), and the cell biology of large dense core vesicles.