Credentials: Medicine Department
Position title: Intracellular trafficking of signaling metabolites
3057 WIMR I
1111 Highland Ave
Madison, WI 53705
Cellular & Molecular Metabolism; Physiology; Transcriptional Mechanisms
My group is interested in understanding the molecular mechanisms that control metabolic adaptation in response to environmental stimuli and in pathophysiological conditions. We are specifically focused on obesity and the role of adipose tissue dysfunction during the progression of obesity and insulin resistance. Adipocyte dysfunction is central to the onset of obesity-associated type 2 diabetes and agents that can restore proper adipocyte function have often shown therapeutic effects in vivo. By integrating chemical proteomics, cellular and biochemical assays, and in-depth mouse phenotyping, we intend to identify novel functional pathways in adipocytes amenable to pharmacological modulation that can provide new avenues to treat obesity and obesity-linked metabolic disorders.