Credentials: Pathology & Laboratory Medicine Department
Position title: Hematopoietic stem cells; bone marrow microenvironment; blood diseases
1111 Highland Ave
Madison, WI 53705
Cancer Biology, Developmental Biology & Regenerative Medicine
The overarching goal of the Gao lab’s research is to understand the functional roles of bone marrow microenvironment in regulating hematopoietic stem cells (HSCs) during normal, pre-malignant and malignant hematopoiesis. Current projects focus on three general areas: 1) understand the functions of nociceptive nerves in regulating HSC behavior and blood diseases; 2) explore the contributions of aged bone marrow microenvironment to age-related blood diseases; 3) investigate the roles of macrophages in the HSC niche. My laboratory combines in vivo and in vitro approaches, including molecular and cellular techniques, mouse models as well as patients-derived xenotransplantation models. Ultimately, we hope that our research will help inform the development of novel strategies to advance the diagnosis, prevention and treatment of blood disorders.