Credentials: Medicine Department
Position title: Cardiac electrophysiology, biophysics, cellular and molecular biology of cardiomyocytes, cardiac arrhythmias and pathophysiology
8455 WIMR II
1111 Highland Ave
Madison 53705 WI
- Developmental Biology & Regenerative Medicine
- Membrane Biology and Protein Trafficking
Our laboratory is a part of the Cellular and Molecular Arrhythmia Research Program (CMARP) involving multiple investigators working on a wide range of research projects exploring the molecular function of ion channels in human physiology, pharmacology, and disease. Our research interests are focused on studying cellular and molecular mechanisms of cardiac excitability and contractility, neurohormonal regulation of cardiac physiology, and mechanisms of abnormal heart rhythms (arrhythmias). We use electrophysiology, cell biology, molecular biology techniques, and various state-of-the art imaging modalities to identify triggers and treatments of cardiac disease. The primary goal of our research is to improve the health of people with cardiac arrhythmias, including the most common abnormal heart rhythm, atrial fibrillation, affecting about 2% to 3% of the Western population. To accomplish this, we aim to identify novel diagnostic tools and therapeutic targets through investigation of mechanisms of cardiac remodeling and arrhythmogenesis.
Our group has a multidisciplinary background that includes expertise in physiology, cell biology, biomedical engineering, biophysics, and confocal microscopy. We employ several state-of-the-art techniques, including high-resolution fluorescent optical mapping and scanning ion conductance microscopy (SICM) equipped with “smart” patch-clamp. This unique set of skills and experimental techniques allow us to investigate mechanisms of arrhythmias across multiple scales from protein expression, localization and function, to electrical and mechanical activity of an intact heart. Our research is specifically focused on elucidating the functionality of subcellular nanodomains and their role in regulation of proteins responsible for normal and pathophysiological electro-mechanical activity of the heart. We pursue two main directions: (1) determining the cellular and molecular mechanisms underlying normal electrical activity and dysfunction of the sinoatrial node, the heart’s natural pacemaker, and (2) discovering novel strategies for atrial fibrillation treatment and risk stratification.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS:
- Molecular and Cellular Pharmacology (MCP)
- Cardiovascular Training Program
- Stem Cell & Regenerative Medicine Center Training Program
COMPLETE LIST OF PUBLICATIONS: