Credentials: Medicine Department
Position title: Cardiac electrophysiology, biophysics, cellular and molecular biology of cardiomyocytes, cardiac arrhythmias and pathophysiology
8455 WIMR II
1111 Highland Ave
Madison 53705 WI
Developmental Biology & Regenerative Medicine; Membrane Biology and Protein Trafficking; Physiology
Our laboratory focuses on understanding the functionality of distinct subcellular microdomains in cardiac myocytes, such as transversal-axial tubules, caveolae, and various costamers, and their functional role in the accumulation, neuro-hormonal and mechanical regulation of proteins responsible for normal and pathophysiological electrical activity of the heart, and how microdomain-targeted remodeling of those proteins contributes to abnormal cardiac electrophysiology and arrhythmogenesis associated with various pathologies. Until recently, the prevailing concept of cardiac electrophysiology has been that ion channels and receptors are freely mobile in the plasma membrane. However, it has been recently recognized that discrete clusters of different ion channels and regulatory receptors are present in the sarcolemma, where they form an interacting network and work together as a part of a macro-molecular signaling complex. This allows the specificity, reliability and accuracy of the autonomic modulation of the excitation–contraction processes by a variety of neurohormonal pathways. Disruption in subcellular targeting of ion channels and associated signaling proteins may contribute to the pathophysiology of a variety of cardiac diseases, including heart failure and certain arrhythmias. This concept extends beyond the classical concept of electric remodeling in heart failure and add a new dimension to cardiovascular disease, besides well-acknowledged changes in protein expression and their posttranslational modifications. Our research combines several state-of-the-art techniques, including highresolution fluorescent optical mapping and scanning ion conductance microscopy (SICM) equipped with “smart” patch-clamp.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Molecular and Cellular Pharmacology (MCP)