Regulation of axon guidance
5433 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
Cell Adhesion & Cytoskeleton; Developmental Biology & Regenerative Medicine; Physiology
The long-term objective of our research is to better understand the intracellular signaling cascades and effector mechanisms responsible for axon outgrowth and pathfinding in the developing central and peripheral nervous systems. For this we must understand how nerve growth cones detect, integrate and respond to soluble and substratum-associated guidance molecules. Mutations in genes involved in the detection and transduction of axon guidance information into directed neurite outgrowth are responsible for many deficits in cognitive function, including autisms, dyslexias and other learning disabilities. By studying the cellular, physiological and molecular mechanisms that govern normal axon outgrowth and guidance, we hope to identify potential sites of therapeutic intervention.