Ophthalmology & Visual Sciences Department
Mechanisms regulating retinal circuit organization
3395 Medical Science Center
1300 University Ave.
Madison, WI 53706
Developmental Biology and Regenerative Medicine; Membrane Biology & Protein Trafficking; Physiology
The Hoon Lab is interested in identifying the cellular, molecular and environmental factors that regulate the formation of stereotypic connectivity between diverse retinal nerve cells during development and that degrade retinal connectivity during disease. Combining multi-transgenic approaches in the mouse retina together with high-resolution light and electron microscopy, single cell profiling and electrophysiological approaches our lab aims to identify both activity-dependent and independent mechanisms that regulate circuit formation and function in the mammalian retina. Knowledge about connectivity disruptions during diseased and degenerating conditions can fuel generation of novel therapeutic tools for mitigating the pathology of blinding diseases.