Peter Lewis

Credentials: Biomolecular Chemistry Department

Position title: Chromatin dynamics in cancer


Phone: (608) 316-4388

2174 Wi Inst For Discovery
333 N Randall Ave
Madison, WI 53715


lab website:

focus groups:

Transcriptional Mechanisms; Cancer Biology

research description:

My research program is rooted in the idea that eukaryotic chromatin, the physiologically relevant form of genomes, contains an indexing system that represents a fundamental regulatory mechanism. Covalent modifications to both DNA and histone proteins allow chromatin to act as a dynamic information hub that integrates diverse biochemical stimuli to regulate genomic DNA access and ultimately establish and maintain cellular identity. Aberrant chromatin regulation, as a consequence of mutation or abnormal signaling is associated with many diseases, especially cancer. The identification of oncogenic mutations has led to the emerging view of “driver mutations” in chromatin regulators underlying many human cancers. My research is aimed at defining how changes in chromatin structure aid in the establishment and maintenance of gene expression programs involved in normal development and tumorigenesis. Ongoing research in the laboratory is directed at describing the molecular mechanisms by which histone H3 mutations drive tumorigenesis, and how the variant histone H3.3 functions in the maintenance of genome integrity in mammals.

ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Biochemistry (IPiB), Genetics, Molecular and Cellular Pharmacology (MCP), Cancer Biology, Cellular and Molecular Pathology (CMP), Molecular and Environmental Toxicology (METC)

perform a pubmed publication search