Darcie Moore
Credentials: Neuroscience Department
Position title: Neural stem cells and aging
Email: darcie.moore@wisc.edu
LAB WEBSITE:
FOCUS GROUPS:
Developmental Biology & Regenerative Medicine, Cell Adhesion and Cytoskeleton
RESEARCH DESCRIPTION:
Our research in adult neurogenesis focuses on the rate-limiting step of this process, which is the exit of neural stem cells from quiescence, and their entry into the cell cycle. We study how these cells regulate proteostasis, including the use of aggresome structures coupled with vimentin cages and their associated proteins to spatially localize proteins that need to be degraded. These proteins are asymmetrically segregated between the 2 daughter cells during division, leading to a difference in the downstream cellular behavior of each daughter. We utilize in vitro and in vivo imaging approaches to visualize cell behavior during this cascade of events. Further, we have established new methods through interdisciplinary collaborations to use label-free autofluorescence imaging of single cells to identify different neural stem cell states, and predict their molecular and transcriptional profile from their dynamic imaging signatures. Lastly, we study how neural stem cells modify their translational control in different cellular states such as
quiescence.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS:
Neuroscience (NTP), Molecular and Cellular Pharmacology (MCP)