Integrative Biology Department
Regeneration and germ cell development in flatworms
3266 Morgridge Inst Research
330 N Orchard St
Madison, WI 53715
Developmental Biology & Regenerative Medicine; Systems Biology
Current research in my laboratory is directed at understanding the mechanisms by which the planarian somatic stem cells produce the germ cells and various differentiated cell lineages in the animal. These studies address fundamental questions pertaining to the establishment, maintenance, and loss of pluripotency, the specification of cell fates during development and homeostasis, the remodeling of differentiated tissues, and how these developmental processes are regulated systemically. More recently, we have been applying our knowledge of planarians to use them as models to understand the biology of parasitic flatworms, with the goal of identifying flatworm-specific molecules or processes that may be targeted to compromise parasite viability or fecundity.