Credentials: Nutritional Sciences Department
Position title: Gene expression regulation of metabolism and aging
1415 Linden Dr.
Madison, WI 53706
Cellular & Molecular Metabolism, Systems Biology
My research program focuses on understanding the molecular regulation of metabolism and aging through the use of caloric restriction (CR). CR is a dietary intervention and model of delayed aging; CR extends lifespan and delays the onset of age-related diseases. CR also triggers substantial reprogramming of cellular and systemic metabolism, but the mechanisms through which this reprogramming is accomplished remain incompletely understood and how this conveys reduced disease risk is still unknown. We examine mechanisms of gene expression regulation, including protein post-translational modifications, mRNA processing, and interaction with microRNA, to understand the CR-driven metabolic program and identify mechanisms that contribute to disease risk.