Marjorie Brand

Credentials: Cell and Regenerative Biology

Position title: Leukemia; Blood differentiation; Gene regulation; Genomics; Proteomics

Email: mbrand3@wisc.edu

Phone: 608-265-9645

Address:
4533 WIMR II
1111 Highland Avenue
Madison, WI 53706

FOCUS GROUPS:

Cancer Biology; Developmental Biology & Regenerative Medicine; Transcriptional Mechanisms

RESEARCH DESCRIPTION:

Hematopoietic Stem cells have the capacity to differentiate along multiple lineages potentially giving rise to
all cells present in the blood. This process is controlled by cell-specific and ubiquitously expressed transcription
factors and cofactors. Defects in the transcriptional regulatory network of these cells can lead to leukemia. The
major goal of the Brand laboratory is to decipher the molecular mechanism of hematopoietic stem cell
differentiation such that we can understand how deregulation of this process can contribute to disease
including leukemia and ß-thalassemia. Towards this goal, we are using a multi-disciplinary approach that
combines in vitro and in vivo techniques in both cell lines and primary human cells. These approaches include
relative and absolute quantitative proteomics (isotope tagged methods), single cell multi-omics (CITEseq,
TEAseq, sc-CUT&Tag, sc-RNAseq) and bioinformatics as well as patients-derived xenotransplantation models
of leukemia and leukemia murine models

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