Pathobiological Sciences Department
T cell responses to viral infections
3174 Veterinary Medicine Building
2015 Linden Dr
Madison, WI 53706
Induction of immunological memory is the basis of vaccinations but the molecular mechanisms underlying the development and maintenance of memory T cells is not well understood. Our research is focused on understanding how signaling pathways and transcriptional factors control the effector T cell fate: terminal differentiation and apoptosis versus survival and differentiation into long-lived memory T cells. We are particularly interested in understanding the PI3K/FoxO/mTOR axis in the differentiation of memory CD8 T cells.