Medical Genetics Department
Neurodegeneration in Drosophila
4262 Genetics-Biotech Center Bldg
425 Henry Mall
Madison, WI 53706
Transcriptional Mechanisms; Developmental Biology & Regenerative Medicine
We are using fruit flies (Drosophila melanogaster) to understand human neuronal disorders. Currently, we are focusing on Ataxia-telangiectasia (A-T) and traumatic brain injury (TBI), both of which are characterized by neuronal degeneration (neurodegeneration) in the central nervous system. We are using genetic and molecular biology approaches to determine the cellular and molecular mechanisms that underlie neurodegeneration. The long-term goal of this research is to identify gene targets for diagnostic and therapeutic intervention in A-T and TBI.