Credentials: Biochemistry Department
Position title: Cryo-electron microscopy of biological macromolecular machines
471B Biochemistry Laboratories
433 Babcock Drive
Madison, WI 53706
Cell Adhesion & Cytoskeleton; Molecular & Genome Biology of Microbes; Virology
My laboratory uses cryo-electron microscopy (cryo-EM) and molecular biology approaches to explore the three-dimensional structure and function of viruses, bacteria, and mammalian cells in order to develop targeted therapeutic agents. Independent projects focus on bacteria and bacteriophage interactions, the structure and function of bacterial appendages, HIV-1 maturation, paramyxovirus and pneumovirus assembly and glycoprotein architecture, and mammalian host cell structure. My laboratory also develops and uses novel cryo-EM and correlative light and electron microscopy technologies to further improve our capacity to address specific questions in cell biology and infectious disease research.