Eric Yen

Credentials: Nutritional Sciences Department

Position title: Intestine, assimilation of dietary fat, and energy balance

Email: eric.yen@wisc.edu

Phone: (608) 890-1888

Address:
340a Nutritional Sciences
1415 Linden Dr
Madison, WI 53706

Headshot

lab website:

https://nutrisci.wisc.edu/c-l-eric-yen/

focus groups:

Cellular & Molecular Metabolism; Physiology

research description:

Triacylglycerol (TAG) serves as reserves of substrates for making cell membranes and generating metabolic energy, and its synthesis intermediates may serve as signaling molecules. TAG is essential for many biological processes; however, excessive accumulation of TAG leads to obesity, diabetes, and related metabolic diseases. Our lab examines the physiological functions of enzymes involved in the synthesis of TAG, focusing on acyl:CoA monoacylglycerol acyltransferase 1 and 2 (MGAT1 and MGAT2). We demonstrated that intestinal MGAT2 regulates food intake and, unexpectedly, energy expenditure. We are now using research approaches from classic biochemistry, molecular and cellular biology, and systems biology to understand how intestinal lipid metabolism regulates systemic energy balance. Our on-going research has expanded into other functions of MGATs and additional genetic and dietary factors modulating energy balance in the broad context of understanding the mechanisms by which nutrition impacts health and disease.

ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Nutritional Sciences (IGPNS), Physiology

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