John Yin

Chemical & Biological Engineering Department

Molecular virology, computational biology, biochemical engineering

john.yin@wisc.edu

(608) 316-4323

3172 Wi Inst For Discovery
333 N Randall Ave
Madison, WI 53715

Headshot

lab website:

https://yin.discovery.wisc.edu/john-yin/

focus groups:

Virology; Systems Biology; Immunology

research description:

We aim to advance a quantitative and integrated understanding how viruses grow and their infections spread. We are developing experimental systems and computational simulations for three single-stranded RNA viruses: vesicular stomatitis virus, a negative-sense RNA virus; and human rhinovirus (HRV) and Zika (ZIKV) virus, both positive-sense RNA viruses. Quantitative experiments are enabling the development of predictive models of growth and spread. Our recent studies entail high-throughput measures of single-cell infections, dual-color virus and host-cell reporters of virus-host interactions, single-cell measures of virus-DIP(defective interfering particle) interaction. Overall, our approaches are directed toward a deeper ‘systems level’ understanding of how viruses grow and cause disease, and we aim to exploit such understanding to develop novel anti-viral strategies that resist escape.

ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Biophysics, Computation and Informatics in Biology and Medicine (CIBM), Genomic Sciences Training Program (GSTP)

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