Bo Liu

Credentials: Surgery Department

Position title: Cell death, signal transduction, extracellular matrix, inflammation, vascular disease

Email: bliu24@wisc.edu

Phone: (608) 263-5931

Address:
5137 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705

LAB WEBSITE:

https://www.surgery.wisc.edu/research/researchers-labs/liu/

FOCUS GROUPS:

Transcriptional Mechanisms, Developmental Biology & Regenerative Medicine, Immunology

RESEARCH DESCRIPTION:

The primary focuses of my basic research include programmed cell death, inflammation, cell-cell communications, extracellular vesicles, as well as matrix biology. Our experimental approach utilizes a combination of cutting-edge technologies including transgenic mice, CRISPR-mediated gene editing, single-cell RNA sequencing, proteomics, and nanotechnology. One of the projects that may be of interest to the CMB students is about how dying cells communicate with surrounding cells and the immune system. In particular, we examine how proteins and miRNAs are packed into extracellular vesicles and how vesicles modify inflammatory responses. Another research project focuses on extracellular matrix in aging and disease. Our in vivo data suggests that inflammation plays a central role in both adaptive and maladaptive responses of the blood vessel wall to mechanical stimuli during hypertension and tissue injuries.

 

ALSO A TRAINER IN THE FOLLOWING PROGRAMS: Cellular and Molecular Pathology (CMP)

PERFORM A PUBMED PUBLICATION SEARCH