Pathology & Laboratory Medicine Department
Host immunity to SIV/HIV and Mtb
585 Science Dr
Madison, WI 53711
We study host immune responses to SIV in nonhuman primates. We are specifically interested in determining which epitopes in SIV elicit effective T cell responses in the host, with an emphasis on understanding the immunogenicity of epitopes in highly conserved regions of the viral genome. This research requires that we construct mutant strains of SIV, assess their replication in vivo, and determine the specificity and function of the T cells that develop in the host. Ultimately, we hope that our research will help inform the development of vaccine immunogens designed to elicit effective T cell immunity to HIV.