Srivatsan Raman
Credentials: Biochemistry Department
Position title: Systems & Synthetic Biology * Protein Engineering * Quantitative Synthetic Biology * Engineering Biological Systems
Email: sraman4@wisc.edu
Phone: (608) 890-1036
Address:
441b Biochemistry
433 Babcock Dr
Madison, WI 53706
LAB WEBSITE:
FOCUS GROUPS:
Molecular & Genome Biology of Microbes; Systems Biology, Transcriptional Mechanisms
RESEARCH DESCRIPTION:
My laboratory develops experimental, computational, and AI-driven approaches to uncover the molecular rules that govern biological function. We combine molecular biology, synthetic biology, protein engineering, functional genomics, machine learning, and artificial intelligence to build high through put platforms that enable the systematic interrogation of biological systems at the scale of genes, proteins, pathways, and entire genomes. These technologies allow us to measure the functional consequences of thousands to millions of genetic perturbations in parallel, enabling biological questions that are difficult or impossible to address using conventional approaches. We apply these technologies to a diverse range of biological systems, including gene regulatory networks, transcription factors, membrane transporters, molecular chaperones, bacterial signaling pathways, bacteriophages, host–virus interactions, and synthetic biological circuits. By systematically perturbing genes, proteins, and genomes and measuring their functional consequences, we seek to understand how biological systems sense information, regulate cellular behavior, evolve new functions,
and interact with one another. Our goal is to uncover generalizable principles that connect genotype to phenotype across diverse biological systems.
Ultimately, we seek to bridge fundamental discovery and biological engineering by developing broadly applicable technologies that advance our understanding of living systems while enabling new applications in biotechnology, synthetic biology, infectious disease, and human health.
ALSO A TRAINER IN THE FOLLOWING PROGRAMS:
Integrated Program in Biochemistry (IPiB), Biophysics, Microbiology Doctoral Training Program (MDTP), Genetics, Chemical and Biological Engineering (CBE)