Lixin Rui
Credentials: Medicine Department
Position title: Cell signaling in B cell lymphoma
Email: lrui@medicine.wisc.edu
Phone: (608) 265-8525
Address:
4053 Wi Institute Medical Research
1111 Highland Ave
Madison, WI 53705
LAB WEBSITE:
FOCUS GROUPS:
Cancer Biology
RESEARCH DESCRIPTION:
The major research focus of my laboratory is the molecular mechanisms of B-cell receptor and JAK-STAT signaling pathways and epigenetic enzymes, including protein arginine methyltransferase 5 (PRMT5) and DNA methyltransferases (DNMTs), in lymphomagenesis.
My research team employs a multidisciplinary approach, using biochemistry, RNA interference, genomic technologies (e.g., ChIP-seq, RNA-seq and single-cell RNA-seq), CRISPR/Cas9 and systems biology methods, to identify mechanisms downstream of the B-cell receptor and JAK-STAT signaling pathways and establish the function of these epigenetic enzymes in B cell lymphoma.
The goal of my research is to discover molecular targets in these pathways for therapeutic, diagnostic and prognostic development of B-cell lymphoma.